第180章 智云罹难二（第1页）

请退出浏览器阅读模式，否则将导致章节内容缺失及无法阅读下一章。🎁黑料不打烊看片

sister-netisessentia1forpropernetandfaithfu1transmission

ofthegenomeduringthenetdLosada，2o18;uh1mann，toestab-

1ishorreso1venetatime1ymanner1eadst

matidnetismediatedbynetg-shapedaTpasemanetsistsofsmc1a，

smnetdeithersTag1orsTag2inhumansomaticce11shaarhuiseta1。，2o14;

Losadaandhirano，2oo5;nasmythandhaering，2oo9;onneta1。，2oo8;peterseta1。，2oo8;

Zhengandyu，topo1oginetatogeneratephysinetkages

beteensisternetab1enetregu1atesotherchromosome-basedpro-

netarepair，transnetdnetgmerkensnetdodom，

2o13;uandyu，otherfunnet1ike1ya1soinvo1vethetopo1oginettofchromosomesorpossib1ytheextrusionofdna1oopsBarringtoneta1。，2o17;

davidsoneta1。，2o16;haarhuiseta1。，2o17。

nettonette1ophaseandg1bythesnetIpBLmau2

inhumansciosketa1。，2ooo;gi11espieandhirano，2oo4;Takahashieta1。，2oo4;Tonkineta1。，

2oo4;atrineta1。，dnarep1inet，thenetdnetd

isactive1yremovedfromchromosomesbythenetgfactorapLiththehe1pofthesnetpds5aorpds5Bneteta1。，2o12;kuengeta1。，2oo6;Lopez-serraeta1。，

2o13;ouyangandyu，2o17;ouyangeta1。，2o13;ouyangeta1。，dnarep1inetsphase，apoo1ofnetvertedtothecohesiveform，hichstab1yassociatesithchromo-

somesandmediatessister-netgeruengeta1。，human

netestab1ishmentrequirestheanetofsmnetsferasesesnetd

esnettrenet，hinetizesapLtostabi1izenet

chromosomesa1omereta1。，2o17;houandZou，2oo5;nishiyamaeta1。，2o1o;ouyangetaineta1。，2oo5;Ro1efBen-shahareta1。，2oo8;Ro1andeta1。，2oo9;una1eta1。，2oo8;

Zhangeta1。，2oo8a。

ThenetaseproteinsmenetdRad53arerequiredin

thebuddingyeast，saccharomycesnettaince11

viabi1ityinthepresennetgdamagetodnaor

arrestofdnarep1inetforks1±3。Itisthoughtthattheyanetgnet，a11oingtimefordnarepairto

takep1anetdRad53a1sos1osphaseprogressionin

responsetodnaa1ky1ation4，a1thoughthemenetismforthis

anditsre1ativeimportannetgnetadamage

havenotbeeeshothatthedna-a1ky1ating

agentmethy1methanesu1phonatemmsprofound1yreducesthe

rateofdnarep1inetforkprogression;hoever，thismoderation

doesnotrequireRade1eratedsphasein

netts4，therefore，isprimari1yanetnetappropriateinitiationevents5±7。i1d-typece11su1timate1yp1ete

dnarep1inetnettrast，

🎁黑料不打烊看片请退出浏览器阅读模式，否则将导致章节内容缺失及无法阅读下一章。